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How is a glucose-rich solution used to increase passage of chemotheraputic agents across the blood-brain barrier:

A) when injected into the subarachnoid space, glucose causes rapid expansion of the ventricles which draw more fluid from blood plasma
B) when injected into the arterial system just prior to drug administration, the glucose causes temporary hypertonicity of the blood which opens tight junctions of the BBB
C) when injected into arterial circulation, glucose is used as a transporter to "carry" the drug across capillary fenestrations in the BBB into the CSF
D) when injected into the CSF, glucose activates transporters on ependymal cells which results in increased active transport into the CSF
E) "a teaspoon of sugar helps the medicine go down"